Exploration of the genomic diversity of third-generation cephalosporin-resistant Escherichia coli in Australian clinical settings

Abstract

Escherichia coli resistant to third-generation cephalosporins (3GCs) is a WHO priority pathogen due to its antimicrobial resistance (AMR). In high-income countries, such as Australia, 3GC-resistant E. coli are a common cause of extra-intestinal infections in both healthcare and community settings. Long-term targeted surveillance efforts of AMR in E. coli routinely identify E. coli as a leading pathogen in bacteraemic infections. To date, there has been limited detailed genomic analysis of the drug-resistant E. coli circulating in Australian clinical settings. Here, we sought to explore the genomic diversity of 3GC-resistant isolates (mediated by extended-spectrum beta-lactamase or AmpC), col..